optimal aminoglycoside therapy following the sepsis: how much is too much?
نویسندگان
چکیده
severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (icus). in the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.aminoglycosides are effective broad-spectrum antibiotics that are commonly used in icus forthe treatment of life-threatening gram-negative infections and as a part of empiric therapy forsevere sepsis and septic shock. knowledge of the pharmacokinetic (pk) and pharmacodynamic(pd) properties of the antibiotics used for the management of critically ill patients is essentialfor selecting the antibiotic dosing regimens and improving patient outcome.volume of distribution (vd) and clearance (cl) of aminoglycosides in critically ill patientsdiffers from general population and these parameters change considerably during the therapy.pathophysiological changes during the sepsis alter the pharmacokinetic and pharmacodynamicprofile of many drugs (increase in vd and variable changes in cl have been reported foraminoglycosides during the sepsis), therefore, dosing regimen optimization is necessary forachieving therapeutic goal, and critically ill patients should receive larger loading doses ofaminoglycosides in order to achieve therapeutic blood levels and due to the considerablevariation in kinetic parameters, the use of standard doses of aminoglycosides or dosingnomograms is not recommended in these populations.
منابع مشابه
Optimal Aminoglycoside Therapy Following the Sepsis: How Much Is Too Much?
Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...
متن کاملOptimal Aminoglycoside Therapy Following the Sepsis: How Much Is Too Much?
Severe sepsis and septic shock are major problems as the result of high rates morbidity andmortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay inthe administration of effective antibiotics is associated with a measurable increase in mortality.Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs forthe treatment of life...
متن کاملOptimal Aminoglycoside Therapy Following the Sepsis: How Much Is Too Much?
Severe sepsis and septic shock are major problems as the result of high rates morbidity and mortality in intensive care units (ICUs). In the presence of septic shock, each hour of delay in the administration of effective antibiotics is associated with a measurable increase in mortality. Aminoglycosides are effective broad-spectrum antibiotics that are commonly used in ICUs for the treatment of ...
متن کاملHow much is too much?
An investigation of the effect of the number of choice sets, starting point and the choice of bid vectors in choice experiments
متن کاملHow much is too much?
The fallout of the Enron debacle spurred legislative and regulatory activity aimed at strengthening corporate governance and preventing another corporate implosion. Confronting shattered investor confidence, Congress responded to these corporate governance fiascos by enacting the now infamous Sarbanes-Oxley Act of 2002. The Securities and Exchange Commission (SEC), meanwhile, called on the self...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۲، شماره ۲، صفحات ۲۶۱-۲۶۹
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023